ABSTRACT
Objective To assist clinical diagnosis of Demodex blepharitis and other related ocular surface disease.Methods 42 cases were collected from the patients diagnosed of blepharitis,dry eye or blepharitis related keratoconjunctivitis (BKC) from the outpatient of the First Hospital of Xi'an City from April and July 2016.The eyelashes were pulled out and detected for the Demodex under microscopy after adding a drop of ethanol.Results 30 cases in 42 patients were detected for the Demodex (the positive rate was 71 ％),while only 1 case in 10 healthy volunteers was detected for the Demodex with the positive rate of 10 ％.The difference between the two groups was statistically significant (x2 =10.23,P＜ 0.01).Conclusion There is a high incidence rate of Demodex blepharitis.The early rapid laboratory diagnosis for Demodex blepharitis should be paid attention to and reinforced,in order to guide the timely and accurate treatment and avoid the occurrence and development of the Demodex related blepharitis,dry eye,BKC or other ocular complications.
ABSTRACT
AIM:To investigate the ocular surface condition among exotropia patients of different age groups by Oculus anterior segment analyzer. METHODS: The ocular surface condition of 66 patients with extropia were examined by Oculus anterior segment analyzer, including tear meniscus height, tear meniscus height after irritation,redness index,non-invasive break-up time(BUT),average BUT. Three groups were divided according to age:2-7 years,8-18 years and 19-46 years. RESULTS: BUT, temporal conjunctival redness index, temporal ciliary redness index,nasal ciliary redness index of 2-7 years group were statistically different to those of 8-18 years group and 19-46 years group. There were no statistically differentiations between redness index at different areas in each group and no statistically differentiations in redness index between dominant eye and nondominant eye(P>0.05). Redness index showed a positive lineal correlation with age. CONCLUSION:Patients are combined with dry eye and unstable tear firm beside strabismus before surgery. Ocular surface assessment should be paid attention to in preschool children in order to prevent complications around operation. Ocular surface data of children with different ages needs to be screened and collected in China.
ABSTRACT
AIM:To investigate the changes of visual development produced by monocular atropinization in rats. METHODS: Twenty normal SD rats were randomly divided into two groups: control group ( n = 10 ) and atropinization ( experimental) group ( n=10 ) . All the left eyes were selected as the experimental eyes, and the right eyes served as the normal eyes. The left eyes in atropinization group was produced by 1% atropine, 3 times a day and the right eyes in control group was treated with normal saline, 3 times a day. The flash visual evoked potentials ( F-VEP ) and retinoscopy refraction of the rats'both eyes were detected at five time points:0, 7, 14, 21, and 28d after atropinization, respectively. After 28d, six rats were randomly selected from both groups and each group had three rats. The expression of the c- fos mRNA was observed in both visual cortexes. Another six rats were chosen for the same test after 2d dark environment with 2h light later. The expression of c-fos mRNA was detected again. RESULTS: After 14d anisometropia was observed in experimental group, the difference was 3. 9D ( P 0.0 5 ) , F-VEP P1 wave of the rats left in experimental group was reached to 88. 9±1. 889ms at 21d, there was statistical difference compared with the right eye ( PCONCLUSION: In the critical period of visual development, monocular chronic atropine in rats can form anisometropia, may delay the transmission of the optic nerve, hinder the normal development of the visual cortex. Monocular atropinization in rats can be used as the model of anisometropia.